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Plos One : Gene Network Analysis in a Pediatric Cohort Identifies Novel Lung Function Genes, Volume 8

By Guo, Wenge

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Book Id: WPLBN0003948893
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Gene Network Analysis in a Pediatric Cohort Identifies Novel Lung Function Genes, Volume 8  
Author: Guo, Wenge
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


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Guo, W. (n.d.). Plos One : Gene Network Analysis in a Pediatric Cohort Identifies Novel Lung Function Genes, Volume 8. Retrieved from

Description : Lung function is a heritable trait and serves as an important clinical predictor of morbidity and mortality for pulmonary conditions in adults, however, despite its importance, no studies have focused on uncovering pediatric-specific loci influencing lung function. To identify novel genetic determinants of pediatric lung function, we conducted a genome-wide association study (GWAS) of four pulmonary function traits, including FVC, FEV1, FEV1/FVC and FEF25–75% in 1556 children. Further, we carried out gene network analyses for each trait including all SNPs with a P-value of ,1.061023 from the individual GWAS. The GWAS identified SNPs with notable trends towards association with the pulmonary function measures, including the previously described INTS12 locus association with FEV1 (pmeta = 1.4161027). The gene network analyses identified 34 networks of genes associated with pulmonary function variables in Caucasians. Of those, the glycoprotein gene network reached genome-wide significance for all four variables. P-value range pmeta = 6.2961024 - 2.8061028 on meta-analysis. In this study, we report on specific pathways that are significantly associated with pediatric lung function at genome-wide significance. In addition, we report the first loci associated with lung function in both pediatric Caucasian and African American populations.


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