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Plos One : Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 Ko Mice, Volume 8

By Federici, Massimo

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Book Id: WPLBN0003950440
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 Ko Mice, Volume 8  
Author: Federici, Massimo
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Federici, M. (n.d.). Plos One : Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 Ko Mice, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Obesity and type 2 diabetes are associated with increased production of Galectin-3 (Gal-3), a protein that modulates inflammation and clearance of glucose adducts. We used Lean and Diet-induced Obese (DIO) WT and Gal-3 KO mice to investigate the role of Gal-3 in modulation of adiposity, glucose metabolism and inflammation. Deficiency of Gal-3 lead to age-dependent development of excess adiposity and systemic inflammation, as indicated by elevated production of acutephase proteins, number of circulating pro-inflammatory Ly6Chigh monocytes and development of neutrophilia, microcytic anemia and thrombocytosis in 20-week-old Lean and DIO male Gal-3 KO mice. This was associated with impaired fasting glucose, heightened response to a glucose tolerance test and reduced adipose tissue expression of adiponectin, Gal-12, ATGL and PPARc, in the presence of maintained insulin sensitivity and hepatic expression of gluconeogenic enzymes in 20- week-old Gal-3 KO mice compared to their diet-matched WT controls. Expression of PGC-1a and FGF-21 in the liver of Lean Gal-3 KO mice was comparable to that observed in DIO animals. Impaired fasting glucose and altered responsiveness to a glucose load preceded development of excess adiposity and systemic inflammation, as demonstrated in 12-week-old Gal-3 KO mice. Finally, a role for the microflora in mediating the fasting hyperglycemia, but not the excessive response to a glucose load, of 12-week-old Gal-3 KO mice was demonstrated by administration of antibiotics. In conclusion, Gal-3 is an important modulator of glucose metabolism, adiposity and inflammation.

 

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