World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Influence of Comt Val158Met Genotype on the Depressed Brain During Emotional Processing and Working Memory, Volume 8

By Domschke, Katharina

Click here to view

Book Id: WPLBN0003950620
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Influence of Comt Val158Met Genotype on the Depressed Brain During Emotional Processing and Working Memory, Volume 8  
Author: Domschke, Katharina
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Domschke, K. (n.d.). Plos One : Influence of Comt Val158Met Genotype on the Depressed Brain During Emotional Processing and Working Memory, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Major depressive disorder (MDD) has been associated with abnormal prefrontal-limbic interactions and altered catecholaminergic neurotransmission. The val158met polymorphism on the catechol-O-methyltransferase (COMT) gene has been shown to influence prefrontal cortex (PFC) activation during both emotional processing and working memory (WM). Although COMT-genotype is not directly associated with MDD, it may affect MDD pathology by altering PFC activation, an endophenotype associated with both COMT and MDD. 125 participants, including healthy controls (HC, n=28) and MDD patients were genotyped for the COMT val158met polymorphism and underwent functional magnetic resonance imaging (fMRI-neuroimaging) during emotion processing (viewing of emotional facial expressions) and a WM task (visuospatial planning). Within HC, we observed a positive correlation between the number of met-alleles and right inferior frontal gyrus activation during emotional processing, whereas within patients the number of met-alleles was not correlated with PFC activation. During WM a negative correlation between the number of met-alleles and middle frontal gyrus activation was present in the total sample. In addition, during emotional processing there was an effect of genotype in a cluster including the amygdala and hippocampus. These results demonstrate that COMT genotype is associated with relevant endophenotypes for MDD. In addition, presence of MDD only interacts with genotype during emotional processing and not working memory.

 

Click To View

Additional Books


  • Plos One : Ttk, Volume 8 (by )
  • Plos One : a Quantitative Comparison of ... (by )
  • Plos One : a MacHine Learning Approach f... (by )
  • Plos One : Directed Pancreatic Acinar Di... (by )
  • Plos One : Differences in Dopaminergic M... (by )
  • Plos One : Easy Dna Modeling and More wi... (by )
  • Plos One : Assessing the Feasibility of ... (by )
  • Plos One : Poor Outcomes in a Cohort of ... (by )
  • Plos One : Comparative Phylogeography of... (by )
  • Plos One : Population Genetic Structure ... (by )
  • Plos One : Multilocus Sequence Typing of... (by )
  • Plos One : Norepinephrine Drives Persist... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.