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Plos One : Integration Host Factor of Mycobacterium Tuberculosis, Mihf, Compacts Dna by a Bending Mechanism, Volume 8

By Ahmed, Niyaz

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Book Id: WPLBN0003950789
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Integration Host Factor of Mycobacterium Tuberculosis, Mihf, Compacts Dna by a Bending Mechanism, Volume 8  
Author: Ahmed, Niyaz
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Ahmed, N. (n.d.). Plos One : Integration Host Factor of Mycobacterium Tuberculosis, Mihf, Compacts Dna by a Bending Mechanism, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : The bacterial chromosomal DNA is folded into a compact structure called as ‘nucleoid’ so that the bacterial genome can be accommodated inside the cell. The shape and size of the nucleoid are determined by several factors including DNA supercoiling, macromolecular crowding and nucleoid associated proteins (NAPs). NAPs bind to different sites of the genome in sequence specific or non-sequence specific manner and play an important role in DNA compaction as well as regulation. Until recently, few NAPs have been discovered in mycobacteria owing to poor sequence similarities with other histone-like proteins of eubacteria. Several putative NAPs have now been identified in Mycobacteria on the basis of enriched basic residues or histone-like ‘‘PAKK’’ motifs. Here, we investigate mycobacterial Integration Host Factor (mIHF) for its architectural roles as a NAP using atomic force microscopy and DNA compaction experiments. We demonstrate that mIHF binds DNA in a non-sequence specific manner and compacts it by a DNA bending mechanism. AFM experiments also indicate a dual architectural role for mIHF in DNA compaction as well as relaxation. These results suggest a convergent evolution in the mechanism of E. coli and mycobacterial IHF in DNA compaction.

 

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