World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Development of Axon-target Specificity of Ponto- Cerebellar Afferents, Volume 9

By Public Library of Science (Plos)

Click here to view

Book Id: WPLBN0003952171
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Development of Axon-target Specificity of Ponto- Cerebellar Afferents, Volume 9  
Author: Public Library of Science (Plos)
Volume: Volume 9
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Of Science (Plos), P. L. (n.d.). Plos Biology : Development of Axon-target Specificity of Ponto- Cerebellar Afferents, Volume 9. Retrieved from http://netlibrary.net/


Description
Description : The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron microscopy revealed that developing pontine mossy fibers elaborate extensive cell-cell contacts and synaptic connections with Purkinje cells, an inappropriate target. Subsequently, mossy fiber–Purkinje cell connections are eliminated resulting in granule cell-specific mossy fiber connectivity as observed in mature cerebellar circuits. Formation of mossy fiber- Purkinje cell contacts is negatively regulated by Purkinje cell-derived BMP4. BMP4 limits mossy fiber growth in vitro and Purkinje cell-specific ablation of BMP4 in mice results in exuberant mossy fiber–Purkinje cell interactions. These findings demonstrate that synaptic specificity in the pontocerebellar projection is achieved through a stepwise mechanism that entails transient innervation of Purkinje cells, followed by synapse elimination. Moreover, this work establishes BMP4 as a retrograde signal that regulates the axon-target interactions during development.

 

Click To View

Additional Books


  • Plos Biology : Control of Jasmonate Bios... (by )
  • Plos Biology : Dna Display I. Sequence-e... (by )
  • Plos Biology : Everything You Always Wan... (by )
  • Plos Biology : Disentangling the Benefit... (by )
  • Plos Biology : Island Mammals”, Volume 5 (by )
  • Plos Biology : Dual Regulation by Pairs ... (by )
  • Plos Biology : Insights Into How Calcium... (by )
  • Plos Biology : the Heart of Medicine, Vo... (by )
  • Plos Biology : Considering the First Ste... (by )
  • Plos Biology : Reconstitution of Dna Str... (by )
  • Plos Biology : Uncoiling Mechanics of Es... (by )
  • Plos Biology : Recruitment, Assembly, an... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.