World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Modeling of Tumor Progression in Nsclc and Intrinsic Resistance to Tki in Loss of Pten Expression, Volume 7

By Ashktorab, Hassan

Click here to view

Book Id: WPLBN0003956984
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Modeling of Tumor Progression in Nsclc and Intrinsic Resistance to Tki in Loss of Pten Expression, Volume 7  
Author: Ashktorab, Hassan
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Ashktorab, H. (n.d.). Plos One : Modeling of Tumor Progression in Nsclc and Intrinsic Resistance to Tki in Loss of Pten Expression, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : EGFR signaling plays a very important role in NSCLC. It activates Ras/ERK, PI3K/Akt and STAT activation pathways. These are the main pathways for cell proliferation and survival. We have developed two mathematical models to relate to the different EGFR signaling in NSCLC and normal cells in the presence or absence of EGFR and PTEN mutations. The dynamics of downstream signaling pathways vary in the disease state and activation of some factors can be indicative of drug resistance. Our simulation denotes the effect of EGFR mutations and increased expression of certain factors in NSCLC EGFR signaling on each of the three pathways where levels of pERK, pSTAT and pAkt are increased. Over activation of ERK, Akt and STAT3 which are the main cell proliferation and survival factors act as promoting factors for tumor progression in NSCLC. In case of loss of PTEN, Akt activity level is considerably increased. Our simulation results show that in the presence of erlotinib, downstream factors i.e. pAkt, pSTAT3 and pERK are inhibited. However, in case of loss of PTEN expression in the presence of erlotinib, pAkt level would not decrease which demonstrates that these cells are resistant to erlotinib.

 

Click To View

Additional Books


  • Plos One : Differential Involvement of B... (by )
  • Plos One : Tweak-independent Fn14 Self-a... (by )
  • Plos One : Passive Experimental Autoimmu... (by )
  • Plos One : Ellagic Acid Derivatives from... (by )
  • Plos One : Probing the Cytoadherence of ... (by )
  • Plos One : Molecular and Clinical Studie... (by )
  • Plos One : Incidence of Liver Damage of ... (by )
  • Plos One : Rationale-based Engineering o... (by )
  • Plos One : Alg-2 Attenuates Copii Buddin... (by )
  • Plos One : Asymmetric Divergence in Stru... (by )
  • Plos One : Lack of Evidence for Mtdna as... (by )
  • Plos One : Quantitative Assessment of Co... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.