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Plos One : Modeling the Role of Negative Cooperativity in Metabolic Regulation and Homeostasis, Volume 7

By Csermely, Peter

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Book Id: WPLBN0003956992
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Modeling the Role of Negative Cooperativity in Metabolic Regulation and Homeostasis, Volume 7  
Author: Csermely, Peter
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Csermely, P. (n.d.). Plos One : Modeling the Role of Negative Cooperativity in Metabolic Regulation and Homeostasis, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : A significant proportion of enzymes display cooperativity in binding ligand molecules, and such effects have an important impact on metabolic regulation. This is easiest to understand in the case of positive cooperativity. Sharp responses to changes in metabolite concentrations can allow organisms to better respond to environmental changes and maintain metabolic homeostasis. However, despite the fact that negative cooperativity is almost as common as positive, it has been harder to imagine what advantages it provides. Here we use computational models to explore the utility of negative cooperativity in one particular context : that of an inhibitor binding to an enzyme. We identify several factors which may contribute, and show that acting together they can make negative cooperativity advantageous.

 

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