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Plos One : the Immediately Releasable Pool of Mouse Chromaffin Cell Vesicles is Coupled to P, Volume 7

By Meunier, Frederic, A.

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Book Id: WPLBN0003961118
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : the Immediately Releasable Pool of Mouse Chromaffin Cell Vesicles is Coupled to P, Volume 7  
Author: Meunier, Frederic, A.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Meunier, F. A. (n.d.). Plos One : the Immediately Releasable Pool of Mouse Chromaffin Cell Vesicles is Coupled to P, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : It is generally accepted that the immediately releasable pool is a group of readily releasable vesicles that are closely associated with voltage dependent Ca2+ channels. We have previously shown that exocytosis of this pool is specifically coupled to P/Q Ca2+ current. Accordingly, in the present work we found that the Ca2+ current flowing through P/Q-type Ca2+ channels is 8 times more effective at inducing exocytosis in response to short stimuli than the current carried by L-type channels. To investigate the mechanism that underlies the coupling between the immediately releasable pool and P/Q-type channels we transiently expressed in mouse chromaffin cells peptides corresponding to the synaptic protein interaction site of Cav2.2 to competitively uncouple P/Q-type channels from the secretory vesicle release complex. This treatment reduced the efficiency of Ca2+ current to induce exocytosis to similar values as direct inhibition of P/Q-type channels via v-agatoxin- IVA. In addition, the same treatment markedly reduced immediately releasable pool exocytosis, but did not affect the exocytosis provoked by sustained electric or high K+ stimulation. Together, our results indicate that the synaptic protein interaction site is a crucial factor for the establishment of the functional coupling between immediately releasable pool vesicles and P/Q-type Ca2+ channels.

 

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