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Plos One : Nicotinic Receptor Β2 Determines Nk Cell-dependent Metastasis in a Murine Model of Metastatic Lung Cancer, Volume 8

By Mattei, Fabrizio

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Book Id: WPLBN0003963884
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Nicotinic Receptor Β2 Determines Nk Cell-dependent Metastasis in a Murine Model of Metastatic Lung Cancer, Volume 8  
Author: Mattei, Fabrizio
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Mattei, F. (n.d.). Plos One : Nicotinic Receptor Β2 Determines Nk Cell-dependent Metastasis in a Murine Model of Metastatic Lung Cancer, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Cigarette smoke exposure markedly compromises the ability of the immune system to protect against invading pathogens and tumorigenesis. Nicotine is a psychoactive component of tobacco products that acts as does the natural neurotransmitter, acetylcholine, on nicotinic receptors (nAChRs). Here we demonstrate that natural killer (NK) cells strongly express nAChR b2. Nicotine exposure impairs the ability of NK cells to kill target cells and release cytokines, a process that is largely abrogated by nAChR b2 deficiency. Further, nicotinic suppression of NF-kB-induced transcriptional activity in NK cells is dependent on nAChR b2. This nAChR subtype also plays a large role in the NK cell-mediated control of melanoma lung metastasis, in a murine lung metastasis model exposed to nicotine. Our findings suggest nAChR b2 as a prominent pathway for nicotine induced impairment of NK cell functions which contributes to the occurrence of smoking-related pathologies.

 

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