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Plos One : Phosphorylated C, Volume 8

By Chatterjee, Bandana

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Book Id: WPLBN0003964652
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Phosphorylated C, Volume 8  
Author: Chatterjee, Bandana
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


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Chatterjee, B. (n.d.). Plos One : Phosphorylated C, Volume 8. Retrieved from

Description : The promoter of the cystic fibrosis transmembrane conductance regulator gene CFTR is tightly controlled by regulators including CCAAT/enhancer binding proteins (C/EBPs). We previously reported that the transcription factors YY1 and USF2 affect CFTR expression. We can now demonstrate that C/EBPb, a member of the CCAAT family, binds to the CFTR promoter and contributes to its transcriptional activity. Our data reveal that C/EBPb cooperates with USF2 and acts antagonistically to YY1 in the control of CFTR expression. Interestingly, YY1, a strong repressor, fails to repress the CFTR activation induced by USF2 through DNA binding competition. Collectively, the data strongly suggest a model by which USF2 functionally interacts with YY1 blocking its inhibitory activity, in favour of C/EBPb transactivation. Further investigation into the interactions between these three proteins revealed that phosphorylation of C/EBPb influences the DNA occupancy of YY1 and favours the interaction between USF2 and YY1. This phosphorylation process has several implications in the CFTR transcriptional process, thus evoking an additional layer of complexity to the mechanisms influencing CFTR gene regulation.


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