World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Promoting Effects of the Adipokine, Apelin, on Diabetic Nephropathy, Volume 8

By Federici, Massimo

Click here to view

Book Id: WPLBN0003965310
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Promoting Effects of the Adipokine, Apelin, on Diabetic Nephropathy, Volume 8  
Author: Federici, Massimo
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Federici, M. (n.d.). Plos One : Promoting Effects of the Adipokine, Apelin, on Diabetic Nephropathy, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Angiogenesis, increased glomerular permeability, and albuminuria are thought to contribute to the progression of diabetic nephropathy (DN). Apelin receptor (APLNR) and the endogenous ligand of APLNR, apelin, induce the sprouting of endothelial cells in an autocrine or paracrine manner, which may be one of the mechanisms of DN. The aim of this study was to investigate the role of apelin in the pathogenesis of DN. Therefore, we observed apelin/APLNR expression in kidneys from patients with type 2 diabetes as well as the correlation between albuminuria and serum apelin in patients with type 2 diabetes. We also measured the proliferating, migrating, and chemotactic effects of apelin on glomerular endothelial cells. To measure the permeability of apelin in glomerular endothelial cells, we used transwells to detect FITC-BSA penetration through monolayered glomerular endothelial cells. The results showed that serum apelin was significantly higher in the patients with type 2 diabetes compared to healthy people (p,0.05, Fig. 1B) and that urinary albumin was positively correlated with serum apelin (R = 0.78, p,0.05). Apelin enhanced the migration, proliferation, and chemotaxis of glomerular endothelial cells in a dose-dependent manner (p,0.05). Apelin also promoted the permeability of glomerular endothelial cells (p,0.05) and upregulated the expression of VEGFR2 and Tie2 in glomerular endothelial cells (p,0.05). These results indicated that upregulated apelin in type 2 diabetes, which may be attributed to increased fat mass, promotes angiogenesis in glomeruli to form abnormal vessels and that enhanced apelin increases permeability via upregulating the expression of VEGFR2 and Tie2 in glomerular endothelial cells

 

Click To View

Additional Books


  • Plos One : Spry1 and Spry4 Differentiall... (by )
  • Plos One : Self-gated Cine Mri for Combi... (by )
  • Plos One : Comprehensive Snp Scan of Dna... (by )
  • Plos One : Does Recall After Sleep-depen... (by )
  • Plos One : Evidence That Head and Body L... (by )
  • Plos One : Altered Functional Connectivi... (by )
  • Plos One : Community Based Promotion on ... (by )
  • Plos One : Escherichia Coli K-12 Survive... (by )
  • Plos One : Moment Approximation of Infec... (by )
  • Plos One : How Effective Are Dna Barcode... (by )
  • Plos One : Human Haemato-endothelial Pre... (by )
  • Plos One : Reconstruction of Danio Rerio... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.