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Plos One : Repressive Effect of Primary Virus Replication on Superinfection Correlated with Gut-derived Central Memory Cd4+ T Cells in Shiv-infected Chinese Rhesus MacAques, Volume 8

By Ambrose, Zandrea

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Book Id: WPLBN0003966004
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Repressive Effect of Primary Virus Replication on Superinfection Correlated with Gut-derived Central Memory Cd4+ T Cells in Shiv-infected Chinese Rhesus MacAques, Volume 8  
Author: Ambrose, Zandrea
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Ambrose, Z. (n.d.). Plos One : Repressive Effect of Primary Virus Replication on Superinfection Correlated with Gut-derived Central Memory Cd4+ T Cells in Shiv-infected Chinese Rhesus MacAques, Volume 8. Retrieved from http://netlibrary.net/


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Description : A possible mechanism of susceptibility to superinfection with simian-human immunodeficiency virus (SHIV)-1157ipd3N4 was explored in twelve SHIVSF162P3-infected Chinese rhesus macaques. Based on the kinetics of viral replication for the second infecting virus following SHIV-1157ipd3N4 inoculation, the monkeys were divided into two groups : those relatively resistant to superinfection (SIR) and those relatively sensitive to superinfection (SIS). We found that superinfection-resistant macaques had high primary viremia, whereas superinfection-sensitive macaques had low primary viremia, suggesting that primary SHIVSF162P3 infection with a high viral-replication level would repress superinfection with a heterologous SHIV- 1157ipd3N4. Although no correlation of protection against superinfection with virus-specific CD4+ T cell or CD8+ T cell immune responses from gut was observed prior to superinfection, superinfection susceptibility was strongly correlated with CD4+ Tcm cells from gut both prior to the second infecting virus inoculation and on day 7 after superinfection, but not with CD4+ Tem cells from gut or with CD4+ Tcm cells from peripheral blood and lymph node. These results point to the important roles of gut-derived CD4+ Tcm cells for the study of the mechanisms of protection against superinfection and the evaluation of the safety and efficacy of vaccines and therapies against acquired immune deficiency syndrome (AIDS).

 

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