World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Spermine and Citrate as Metabolic Biomarkers for Assessing Prostate Cancer Aggressiveness, Volume 8

By Monleon, Daniel

Click here to view

Book Id: WPLBN0003967009
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Spermine and Citrate as Metabolic Biomarkers for Assessing Prostate Cancer Aggressiveness, Volume 8  
Author: Monleon, Daniel
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


APA MLA Chicago

Monleon, D. (n.d.). Plos One : Spermine and Citrate as Metabolic Biomarkers for Assessing Prostate Cancer Aggressiveness, Volume 8. Retrieved from

Description : Separating indolent from aggressive prostate cancer is an important clinical challenge for identifying patients eligible for active surveillance, thereby reducing the risk of overtreatment. The purpose of this study was to assess prostate cancer aggressiveness by metabolic profiling of prostatectomy tissue and to identify specific metabolites as biomarkers for aggressiveness. Prostate tissue samples (n = 158, 48 patients) with a high cancer content (mean : 61.8%) were obtained using a new harvesting method, and metabolic profiles of samples representing different Gleason scores (GS) were acquired by high resolution magic angle spinning magnetic resonance spectroscopy (HR-MAS). Multivariate analysis (PLS, PLS-DA) and absolute quantification (LCModel) were used to examine the ability to predict cancer aggressiveness by comparing low grade (GS = 6, n = 30) and high grade (GS$7, n = 81) cancer with normal adjacent tissue (n = 47). High grade cancer tissue was distinguished from low grade cancer tissue by decreased concentrations of spermine (p = 0.0044) and citrate (p = 7.73?1024), and an increase in the clinically applied (total choline+creatine+polyamines)/citrate (CCP/C) ratio (p = 2.17?1024). The metabolic profiles were significantly correlated to the GS obtained from each tissue sample (r = 0.71), and cancer tissue could be distinguished from normal tissue with sensitivity 86.9% and specificity 85.2%. Overall, our findings show that metabolic profiling can separate aggressive from indolent prostate cancer. This holds promise for the benefit of applying in vivo magnetic resonance spectroscopy (MRS) within clinical MR imaging investigations, and HR-MAS analysis of transrectal ultrasound-guided biopsies has a potential as an additional diagnostic tool.


Click To View

Additional Books

  • Plos One : a Discrete Electromechanical ... (by )
  • Plos One : Impaired Eye Region Search Ac... (by )
  • Plos One : Age-related Differences in Co... (by )
  • Plos One : Pyrolytic and Kinetic Charact... (by )
  • Plos One : Small Intestinal Nematode Inf... (by )
  • Plos One : Pre-evaluated Safe Human Ipsc... (by )
  • Plos One : Role of Centrins 2 and 3 in O... (by )
  • Plos One : Physical Activity and Lung Fu... (by )
  • Plos One : Detection of Osteogenic Diffe... (by )
  • Plos One : Protein Complex Formation ; C... (by )
  • Plos One : Therapeutic Options in Doceta... (by )
  • Plos One : the Mitochondrion-like Organe... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.