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Plos One : Staphylococcus Aureus Activates the Nlrp3 Inflammasome in Human and Rat Conjunctival Goblet Cells, Volume 8

By Fleiszig, Suzanne

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Book Id: WPLBN0003967054
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Staphylococcus Aureus Activates the Nlrp3 Inflammasome in Human and Rat Conjunctival Goblet Cells, Volume 8  
Author: Fleiszig, Suzanne
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
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Publisher: Plos

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Fleiszig, S. (n.d.). Plos One : Staphylococcus Aureus Activates the Nlrp3 Inflammasome in Human and Rat Conjunctival Goblet Cells, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : The conjunctiva is a moist mucosal membrane that is constantly exposed to an array of potential pathogens and triggers of inflammation. The NACHT, leucine rich repeat (LRR), and pyrin domain-containing protein 3 (NLRP3) is a Nod-like receptor that can sense pathogens or other triggers, and is highly expressed in wet mucosal membranes. NLRP3 is a member of the multi-protein complex termed the NLRP3 inflammasome that activates the caspase 1 pathway, inducing the secretion of biologically active IL-1b, a major initiator and promoter of inflammation. The purpose of this study was to : (1) determine whether NLRP3 is expressed in the conjunctiva and (2) determine whether goblet cells specifically contribute to innate mediated inflammation via secretion of IL-1b. We report that the receptors known to be involved in the priming and activation of the NLRP3 inflammasome, the purinergic receptors P2X4 and P2X7 and the bacterial Toll-like receptor 2 are present and functional in conjunctival goblet cells. Toxin-containing Staphylococcus aureus (S. aureus), which activates the NLRP3 inflammasome, increased the expression of the inflammasome proteins NLRP3, ASC and pro- and mature caspase 1 in conjunctival goblet cells. The biologically active form of IL-1b was detected in goblet cell culture supernatants in response to S. aureus, which was reduced when the cells were treated with the caspase 1 inhibitor Z-YVAD. We conclude that the NLRP3 inflammasome components are present in conjunctival goblet cells. The NRLP3 inflammasome appears to be activated in conjunctival goblet cells by toxin-containing S. aureus via the caspase 1 pathway to secrete mature IL1-b. Thus goblet cells contribute to the innate immune response in the conjunctiva by activation of the NLRP3 inflammasome.

 

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