World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : the Axonal Guidance Cue Semaphorin 3C Contributes to Alveolar Growth and Repair, Volume 8

By Morty, Rory, Edward

Click here to view

Book Id: WPLBN0003967683
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : the Axonal Guidance Cue Semaphorin 3C Contributes to Alveolar Growth and Repair, Volume 8  
Author: Morty, Rory, Edward
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Morty, R. E. (n.d.). Plos One : the Axonal Guidance Cue Semaphorin 3C Contributes to Alveolar Growth and Repair, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Lung diseases characterized by alveolar damage such as bronchopulmonary dysplasia (BPD) in premature infants and emphysema lack efficient treatments. Understanding the mechanisms contributing to normal and impaired alveolar growth and repair may identify new therapeutic targets for these lung diseases. Axonal guidance cues are molecules that guide the outgrowth of axons. Amongst these axonal guidance cues, members of the Semaphorin family, in particular Semaphorin 3C (Sema3C), contribute to early lung branching morphogenesis. The role of Sema3C during alveolar growth and repair is unknown. We hypothesized that Sema3C promotes alveolar development and repair. In vivo Sema3C knock down using intranasal siRNA during the postnatal stage of alveolar development in rats caused significant air space enlargement reminiscent of BPD. Sema3C knock down was associated with increased TLR3 expression and lung inflammatory cells influx. In a model of O2-induced arrested alveolar growth in newborn rats mimicking BPD, air space enlargement was associated with decreased lung Sema3C mRNA expression. In vitro, Sema3C treatment preserved alveolar epithelial cell viability in hyperoxia and accelerated alveolar epithelial cell wound healing. Sema3C preserved lung microvascular endothelial cell vascular network formation in vitro under hyperoxic conditions. In vivo, Sema3C treatment of hyperoxic rats decreased lung neutrophil influx and preserved alveolar and lung vascular growth. Sema3C also preserved lung plexinA2 and Sema3C expression, alveolar epithelial cell proliferation and decreased lung apoptosis. In conclusion, the axonal guidance cue Sema3C promotes normal alveolar growth and may be worthwhile further investigating as a potential therapeutic target for lung repair.

 

Click To View

Additional Books


  • Plos One : Modeling of Tumor Progression... (by )
  • Plos One : Caregivers in China ; Knowled... (by )
  • Plos One : Interactions Between the R2R3... (by )
  • Plos One : Maternal Deprivation Enhances... (by )
  • Plos One : Hepatocyte Growth Factor Acti... (by )
  • Plos One : Galectin-3 Functions as an Al... (by )
  • Plos One : the Spectrum of Podoplanin Ex... (by )
  • Plos One : Mhc Class I-presented T Cell ... (by )
  • Plos One : Mesenchymal Stem Cells Develo... (by )
  • Plos One : Vascular Dysfunction Followin... (by )
  • Plos One : Respiratory Syncytial Virus R... (by )
  • Plos One : Interactogeneous ; Disease Ge... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.