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Plos One : the Ciliary Protein Ftm is Required for Ventricular Wall and Septal Development, Volume 8

By Dettman, Robert

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Book Id: WPLBN0003967737
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : the Ciliary Protein Ftm is Required for Ventricular Wall and Septal Development, Volume 8  
Author: Dettman, Robert
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Dettman, R. (n.d.). Plos One : the Ciliary Protein Ftm is Required for Ventricular Wall and Septal Development, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Ventricular septal defects (VSDs) are the most common congenital heart defects in humans. Despite several studies of the molecular mechanisms involved in ventricular septum (VS) development, very little is known about VS-forming signaling. We observed perimembranous and muscular VSDs in Fantom (Ftm)-negative mice. Since Ftm is a ciliary protein, we investigated presence and function of cilia in murine hearts. Primary cilia could be detected at distinct positions in atria and ventricles at embryonic days (E) 10.5–12.5. The loss of Ftm leads to shortened cilia and a reduced proliferation in distinct atrial and ventricular ciliary regions at E11.5. Consequently, wall thickness is diminished in these areas. We suggest that ventricular proliferation is regulated by cilia-mediated Sonic hedgehog (Shh) and platelet-derived growth factor receptor a (Pdgfra) signaling. Accordingly, we propose that primary cilia govern the cardiac proliferation which is essential for proper atrial and ventricular wall development and hence for the fully outgrowth of the VS. Thus, our study suggests ciliopathy as a cause of VSDs.

 

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