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Plos One : the Differential Antiviral Activities of Chicken Interferon Α Chifn-α and Chifn-β Are Related to Distinct Interferon-stimulated Gene Expression, Volume 8

By Valledor, Annabel

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Book Id: WPLBN0003967827
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : the Differential Antiviral Activities of Chicken Interferon Α Chifn-α and Chifn-β Are Related to Distinct Interferon-stimulated Gene Expression, Volume 8  
Author: Valledor, Annabel
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
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Publisher: Plos

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Valledor, A. (n.d.). Plos One : the Differential Antiviral Activities of Chicken Interferon Α Chifn-α and Chifn-β Are Related to Distinct Interferon-stimulated Gene Expression, Volume 8. Retrieved from http://netlibrary.net/


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Description : Chicken interferon a (ChIFN-a) and ChIFN-b are type I IFNs that are important antiviral cytokines in the innate immune system. In the present study, we identified the virus-induced expression of ChIFN-a and ChIFN-b in chicken fibroblast DF-1 cells and systematically evaluated the antiviral activities of recombinant ChIFN-a and ChIFN-b by cytopathic-effect (CPE) inhibition assays. We found that ChIFN-a exhibited stronger antiviral activity than ChIFN-b in terms of inhibiting the replication of vesicular stomatitis virus, Newcastle disease virus and avian influenza virus, respectively. To elucidate the mechanism of differential antiviral activities between the two ChIFNs, we measured the relative mRNA levels of IFNstimulated genes (ISGs) in IFN-treated DF-1 cells by real-time PCR. ChIFN-a displayed greater induction potency than ChIFNb on several ISGs encoding antiviral proteins and MHC-I, whereas ChIFN-a was less potent than ChIFN-b for inducing ISGs involved in signaling pathways. In conclusion, ChIFN-a and ChIFN-b presented differential induction potency on various sets of ISGs, and the stronger antiviral activity of ChIFN-a is likely attributed to the greater expression levels of downstream antiviral ISGs.

 

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