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Plos One : the Gdnf System is Altered in Diverticular Disease – Implications for Pathogenesis, Volume 8

By Skoulakis, Efthimios, M. C.

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Book Id: WPLBN0003968020
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : the Gdnf System is Altered in Diverticular Disease – Implications for Pathogenesis, Volume 8  
Author: Skoulakis, Efthimios, M. C.
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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C. Skoulaki, E. M. (n.d.). Plos One : the Gdnf System is Altered in Diverticular Disease – Implications for Pathogenesis, Volume 8. Retrieved from http://netlibrary.net/


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Description : Our results suggest that the GDNF system is compromised in DD. In vitro studies demonstrate that GDNF enhances expression of its receptors and promotes enteric neuronal differentiation and plasticity. Since patients with DD exhibit hypoganglionosis, we propose that the observed enteric neuronal loss in DD may be due to lacking neurotrophic support mediated by the GDNF system.

 

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