World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : the Hierarchical Process of Differentiation of Long-lived Antibody-secreting Cells is Dependent on Integrated Signals Derived from Antigen and Il-17A, Volume 8

By Bansal, Geetha, P.

Click here to view

Book Id: WPLBN0003968061
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : the Hierarchical Process of Differentiation of Long-lived Antibody-secreting Cells is Dependent on Integrated Signals Derived from Antigen and Il-17A, Volume 8  
Author: Bansal, Geetha, P.
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Bansal, G. P. (n.d.). Plos One : the Hierarchical Process of Differentiation of Long-lived Antibody-secreting Cells is Dependent on Integrated Signals Derived from Antigen and Il-17A, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Switched CD19-positive memory B cells purified from mice with chronic immune response against Thalassophryne nattereri venom proteins were cultured with venom or cytokines. Our results confirm the existence of a hierarchic process of differentiation : activated memory B cells progressively acquire increasing levels of CD138 and decreasing levels of CD45R/B220 to finally arrive at ASC with B220neg phenotype, which are IgG1-secreting cells. Only Bmem from peritoneal cavity or bone marrow of VTn immunized mice presented the capacity to generate ASC functionally active. IL-17A or IL-21/IL-23/IL-33 improves the ability of venom to induce intracellular IgG of peritoneal derived-ASC. Cognate stimulation with venom and IL-17A is sufficient to down-regulate the expression of CD45R/B220. BAFF-R is up-regulated in splenic or medullar derived-ASC stimulated by venom, CpG or cytokines. Only splenic derived-ASC up-regulate Bcl-2 expression after CpG or the combination of IL-21/IL-23/IL-33 stimulation. Finally, the activation of ASC for IgG1 secretion is triggered by venom proteins in peritoneal cavity and by IL-17A in medullar niche. These results show the importance of the integration of signals downstream of BCR and IL17-A receptors in modulating ASC differentiation, focusing in the microenvironment niche of their generation

 

Click To View

Additional Books


  • Plos One : Children with Adhd Symptoms H... (by )
  • Plos One : Intake of Farmed Atlantic Sal... (by )
  • Plos One : the Dmd Locus Harbours Multip... (by )
  • Plos One : a Reporter Screen in a Human ... (by )
  • Plos One : Consequences of Increasing Hy... (by )
  • Plos One : Targeted Interventions for Im... (by )
  • Plos One : Improving Ethanol Tolerance o... (by )
  • Plos One : Unexplored Character Diversit... (by )
  • Plos One : Differential Requirements in ... (by )
  • Plos One : Don’t Rock the Boat ; How Ant... (by )
  • Plos One : Social and Geographical Inequ... (by )
  • Plos One : the Role of Propagule Pressur... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.