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Plos One : the Linker Pivot in Ci-vsp ; the Key to Unlock Catalysis, Volume 8

By Barnes, Steven

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Book Id: WPLBN0003968198
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : the Linker Pivot in Ci-vsp ; the Key to Unlock Catalysis, Volume 8  
Author: Barnes, Steven
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Barnes, S. (n.d.). Plos One : the Linker Pivot in Ci-vsp ; the Key to Unlock Catalysis, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : In the voltage-sensitive phosphatase Ci-VSP, conformational changes in the transmembrane voltage sensor domain (VSD) are transduced to the intracellular catalytic domain (CD) leading to its dephosphorylation activity against membraneembedded phosphoinositides. The linker between both domains is proposed to be crucial for the VSD-CD coupling. With a combined approach of electrophysiological measurements on Xenopus oocytes and molecular dynamics simulations of a Ci- VSP model embedded in a lipid bilayer, we analyzed how conformational changes in the linker mediate the interaction between the CD and the activated VSD. In this way, we identified specific residues in the linker that interact with welldefined amino acids in one of the three loops forming the active site of the protein, named TI loop. With our results, we shed light into the early steps of the coupling process between the VSD and the CD, which are based on fine-tuned electrostatic and hydrophobic interactions between the linker, the membrane and the CD.

 

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